HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Enum\PCI\\\Device Parameters The registry entry is configured to have a DWORD value of 1. This value enables the Soft-Retry code path that is used in this hotfix. Note To obtain and , open the Device Manager property page for each EHCI USB host controller, click the Details tab, and then select Device Instance Path in the list. Most systems have only one or two EHCI host controllers, so this should not be too difficult.
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Regulatory T (Treg) cells, generated along with thymocyte development or through CD4+ T-cell differentiation, are instrumental for controlling immune responses to prevent autoimmunity and chronic inflammation.46 Although NF-κB is known as a factor that promotes T-cell activation and effector T-cell differentiation, it is increasingly clear that the function of NF-κB in T-cell responses is paradoxical, since it is also involved in the generation of Treg cells. Mice deficient in various signaling components of the canonical NF-κB pathway, such as TAK1, IKK and the T-cell-specific TAK1/IKK-activating factors CARMA1 and Bcl10, have reduced production of Treg cells, whereas expression of a constitutive active IKKβ or deletion of the IKK-negative regulator CYLD promotes Treg development.47 The NF-κB member c-Rel is particularly important for mediating Treg development, and c-Rel acts by participating in the induction of Treg master transcription factor Foxp3.48,49 The canonical NF-κB signaling pathway is also required for maintaining the immunosuppressive function of Treg cells, since deletion of IKKβ or its upstream activator Ubc13 in Treg cells impairs the in vivo function of Treg cells and sensitizes Treg cells for acquiring Th1 and Th17 inflammatory effector functions under lymphopenic conditions.50 2ff7e9595c
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